Improving Genome Assembly without Sequencing
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چکیده
Assembly of genomes from whole-genome sequencing (WGS) projects is one of the most complex computational problems in genomics. WGS assemblers such as Arachne [1] and Celera Assembler [2] are able to process data from millions of individual sequence "reads" and construct an accurate representation of a genome. These assemblies are in the form of contigs (contiguous stretches of DNA sequence) and scaffolds (contigs linked by information from paired-end sequences).
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تاریخ انتشار 2005